What does glucose-6-phosphate translocase do?

What does glucose-6-phosphate translocase do?

The translocase transports glucose-6-phosphate into the lumen of the endoplasmic reticulum, where it is hydrolyzed into glucose and inorganic phosphate. Absence of translocase results in an inability to liberate glucose from glucose-6-phosphate.

Can glucose-6-phosphate cross the membrane?

The major reason for the immediate phosphorylation of glucose is to prevent diffusion out of the cell. The phosphorylation adds a charged phosphate group so the glucose 6-phosphate cannot easily cross the cell membrane.

Where is glucose-6-phosphatase found in the body?

liver
Glucose-6-phosphatase (G6Pase), an enzyme found mainly in the liver and the kidneys, plays the important role of providing glucose during starvation. Unlike most phosphatases acting on water-soluble compounds, it is a membrane-bound enzyme, being associated with the endoplasmic reticulum.

What would build up in a cell if glucose-6-phosphatase was missing?

…the absence of the enzyme glucose-6-phosphatase, which regulates the release of the simple sugar glucose from glycogen stored in the liver. This results in an abnormal accumulation of glycogen in the liver, causing the liver to enlarge and producing symptoms of hypoglycemia (low blood sugar) and hyperuricemia (gout).

Where is glucose-6-phosphate mainly used?

Glucose-6-phosphate is readily utilized for the synthesis and storage of glycogen and its metabolism is enhanced to pyruvate via the glycolytic pathway due to the action of several regulatory enzymes under the control of insulin-mediated actions.

Is glucose-6-phosphatase the same as glucose-6-phosphate dehydrogenase?

Abstract. GLUCOSE-6-PHOSPHATASE and glucose-6-phosphate dehydrogenase (G6PD) are both important enzymes; a deficiency of either of these enzymes can cause the infant to have significant or life-threatening symptoms.

Is glucose 6-phosphate toxic to cells?

Chemical reactions involving glucose-6-phosphate dehydrogenase produce compounds that prevent reactive oxygen species from building up to toxic levels within red blood cells.

Where is glucose 6-phosphate mainly used?

Is glucose-6-phosphatase present in muscle?

There does not appear to be glucose 6-phosphatase in skeletal muscle; hence, muscle glycogen is not a source of circulating glucose.

What is the consequence of an overproduction of glucose-6-phosphate?

Glucose-6-phosphatase deficiency results in hypoglycemia and excessive intracellular accumulation of glucose-6-phosphate (Fig. 43-2). Hypoglycemia may produce lethargy, coma, seizures and brain damage in gluconeogenic and glycogen synthetase deficiencies.

Is glucose 6-phosphatase present in muscle?

Is glucose-6-phosphate toxic to cells?