Why is uric acid high in leukemia?

Why is uric acid high in leukemia?

Death of proliferating leukemia cells leads to the overloading of purine nucleic acids in the blood of the patients. These purine nucleotides are subsequently catabolized to hypoxanthine, xanthine, and, finally, UA by xanthine oxidase (15, 16).

Is uric acid levels decreased in leukemia?

in patients with leukemias and other neoplastic diseases1 and have consist- ently found increases in serum and urine uric acid in patients with chronic granulocytic leukemia. This is in contrast to patients with chronic lymphocytic leukemia, in whom serum and urine uric acid have been normal (Table 11).

Can cancer cause high uric acid?

Certain cancers, or chemotherapy agents may cause an increased turnover rate of cell death. This is usually due to chemotherapy, but high uric acid levels can occur before chemotherapy is administered. After chemotherapy, there is often a rapid amount of cellular destruction, and tumor lysis syndrome may occur.

Why is uric acid elevated in cancer?

It is also not rare for cancer patients, especially patients with lymphocytic leukemia and Burkitt’s lymphoma, to have a high SUA level, among whom a high plasma uric acid level may occur as a result of increased purine metabolism by xanthine oxidase as a consequence of tumor cell breakdown 28.

What causes too much uric acid?

Excess uric acid can be the result of several factors, including: drinking too much alcohol. eating foods that contain a substance called purines, which get broken down to become uric acid. taking certain medicines, such as diuretics or aspirin (Bayer) having kidney disease.

What are the side effects of high uric acid?

Of all the side effects one can develop from having too much uric acid in the system, gout is by far the most common and one of the most painful. The more animal-based proteins a person eats, the more uric acid is produced through the breakdown of purines, a byproduct of protein digestion, explains the University of Maryland Medical Center.

Can you cure leukemia?

Some leukemia patients can be cured, but in other situations the disease can only be controlled. Treatments include chemotherapy, radiation and stem cell transplants. Even when in remission, continuing therapy may be needed to keep the leukemia from recurring.

What are the causes and effects of leukemia?

Leukemia can be caused by radiation exposure or due to chain smoking or exposure to excessive amounts of smoke. Acute leukemia symptoms are headaches, vomiting, confusion, loss of muscle control, or seizures. They also affect other parts of the body like digestive tract, kidneys, lungs, heart or testes.